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Tumour growth and chemotherapy

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Tumour growth can be described in terms of the multiple of functions of:

  • the cell cycle time, T
  • the growth fraction, G
  • the rate of cell loss, L i.e.: fT x fG x fL = tumour doubling time

G is proportional to tumour mass, such that larger tumours have a smaller growth fraction - Gompertzian growth. Thus small tumours grow faster

From this, problems with chemotherapy in solid tumours are as follows:

  • low growth fraction
  • poor drug penetration
  • intrinsic drug resisitance
  • develepment of drug resistance

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