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Prostatic acid phosphatase

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Prostatic acid phosphatase is used by some centres as an indicator of prostatic carcinoma as a raised value suggests spread beyond the capsule.

However:

  • a normal PAP does not exclude carcinoma
  • PAP is normal in 20% of patients with metastases
  • PAP may be falsely elevated by urethral instrumentation
  • the isoenzyme is unstable and must be sent for assay as soon as possible

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