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Mannose binding protein dysfunction

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Mutations in the gene for the mannose binding protein (MBP) may result in defective opsonisation. This common form of immuno-deficiency causes recurrent infections in children and severe and unusual infections in adults.

MBP mutations are found in 25% of children with unexplained recurrent bacterial and fungal infections (1).

The normal form of MBP may have a role in the pathogenesis of rheumatoid arthritis.

Reference:

  • Summerfield JA et al. (1995). Mannose binding protein gene mutations associated with unusual and severe infections in adults. Lancet, 345, 886-89.

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