Prednisolone is a synthetic glucocorticoid widely used for its anti-inflammatory and immunosuppressive actions. It is the most frequently used steroid for chronic prolonged oral therapy.
It has 400% of the anti-inflammatory potency of hydrocortisone but only 80% of its sodium-retaining ability.
In acute inflammation, an initial daily dose of 40-60mg may be necessary; if the desired response is obtained, the dose is reduced gradually over the course of a few weeks to a maintenance level of 5-15 mg.
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