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Isocitrate dehydrogenase

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Isocitrate dehydrogenase is actually 2 slightly different mitochondrial enzymes which convert 6 carbon isocitrate into 5 carbon 2-oxoglutarate during the tricarboxylic acid cycle. One enzyme reduces NAD during the reaction, the other reduces NADPH.

Also, 1 molecule of carbon dioxide is produced during the reaction.

The molecule of NAD(P)H can produce 3 molecules of ATP via the electron transport chain.

Isocitrate dehydrogenase is one target for TCA cycle modulation.


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