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Differential diagnosis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Several rare diseases may be mistaken for rickets on clinical, radiological or histological grounds. The differential includes:

  • hypophosphatasia - genetic deficiency of alkaline phosphatase with both autosomal recessive and dominant forms. The recessive disease presents as gross rickets and has a poor prognosis.
  • marble bone disease
  • chondrodysplasia - grossly disorganised growth plates resulting in severe bow legs. Osteotomies heal normally.
  • Blount's disease

Reference:

  • Chanchlani R. An Overview of Rickets in Children. Kidney Int Rep. 2020 Apr 11;5(7):980-990

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