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Ubiquinone dehydrogenase

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Ubiquinone dehydrogenase is a large enzyme complex within the inner mitochondrial membrane. It is an intermediate in the electron transfer chain.

It consists of:

  • cytochrome b:
    • has haem prosthetic group
    • accepts electrons from ubiquinone to produce an Fe 2+ redox state
    • transfers electron to ubiquinol to recycle Fe 3+ state
  • ubiquinol: transfers electron to ferrous carrier by oxidation
  • ferrous carrier: transfers electron to cytochrome c1 by oxidation
  • cytochrome c1:
    • contains haem prosthetic group
    • reduced by transfer of electrons from ferrous carrier
    • reoxidized by transfer of electrons to cytochrome c

The passage of 1 electron through the ubiquinone dehydrogenase complex acts to pump 1 proton into the mitochondrial intermembranous space. Ultimately, this produces 1 molecule of ATP through oxidative phosphorylation.

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