This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages without signing in

Chloramphenicol

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Chloramphenicol is an antibacterial and antirickettsial which should be reserved for the treatment of severe life-threatening infections due to H. influenzae and typhoid fever since when given parenterally it may be toxic .

Chloramphenicol acts to inhibit peptidyl transferase on 70S ribosomes such that it prevents peptide bond formation.

Cautions:

  • FBC needed before and during treatment on a regular basis
  • neonates - grey baby syndrome
  • beware interactions - see current issue BNF
  • avoid repeated course and prolonged treatment
  • reduce doses in hepatic or renal failure

Contra-indications include:

  • pregnancy and breast feeding
  • porphyria

Routes of administration:

  • oral:
    • capsules
    • suspension
  • i.v. injection
  • i.v. infusion

Check the Summary of Product Characteristics before prescribing

Related pages

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.