osteogenesis imperfecta type IV - moderately severe disease

Last reviewed 01/2018

Type IV osteogenesis imperfecta a moderately severe form of the condition.

Type IV is differentiated from the type I form by white sclera, and from the type III form by not being progressively deforming.


  • with respect to classification of osteogenesis imperfecta
    • the broad clinical and biomolecular spectrum mean that any classification is unable to be complete or accurate - however it represents a practical tool for the clinician dealing with management of patients


  1. Devogalaer JP. New uses of bisphosphonates: osteogenesis imperfecta. Curr Opin Pharmacol. 2002 Dec;2(6):748-53.