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Monoamine oxidase inhibitors and hypertension

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

  • monoamine oxidase inhibitors (MAOIs) can cause a sudden hypertensive crisis by irreversibly blocking the breakdown of catecholamines following the consumption of foods containing catecholamine releaser tyramine (1)

  • MAOIs (including meclobemide) should be avoided in patients who have experienced a hypertensive crisis (2)

Reference:

  • 1) Blackwell B et al (1967). Hypertensive interactions between monoamine oxidase inhibitors and foodstuffs. Br J Psychiatry, 113, 349-65.
  • 2) Prescribers' Journal (2000), 40 (2), 169-174.

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