Last reviewed 02/2023

Methotrexate is an antifolate drug used in chemotherapy. Its action is to bind dihydrofolate reductase.

It is indicated for the treatment of various malignancies at high dose and for the treatment of psoriasis and rheumatoid arthritis as a titrated weekly dose (1).

The summary of product characteristics should be consulted before prescribing this drug.


  • (1) Current Problems in Pharmacovigilance (2000), 26, 10.