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Fusidic acid

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Fusidic acid is a narrow spectrum antibiotic with a steroid like structure which prevents the translocation step of bacterial peptide synthesis by inhibiting factor G.

Its only indication is infections due to penicillin resistant Staphylococci, especially osteomyelitis since fusidic acid is concentrated in bone. A second antistaphylococcal agent is also required to prevent the development of resistance.

Cautions:

  • liver function tests required

Side-effects:

  • rashes
  • reversible jaundice
  • nausea and vomiting

Routes of administration:

  • oral:
    • tablets
    • suspension
  • i.v. infusion

Note that topical preparations of fusidic acid are also available:

  • fusidic acid eye drops - useful treatment for staphylococcal superficial eye infections
  • fusidic acid (in the form of ointment or cream) is available for the treatment of staphylococcal skin infections; preparations of fusidic acid combined with a topical steroid is a useful agent for treatment of infected eczema/dermatitis

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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