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Myeloproliferative disease

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Myeloproliferative disorders are a heterogenous group of disorders which result from clonal neoplastic proliferation of one or more myeloid stem cells. Each disorder produces a characteristic syndrome with well-defined clinical and laboratory features but they are grouped together since one disease may evolve into another and all may progress to acute myeloid leukaemia.

Specific types are named according to the predominant differentiation pathway followed:

  • chronic myeloid (granulocytic) leukaemia - myeloid differentiation
  • polycythaemia vera - erythroid differentiation
  • essential thrombocythaemia - platelet differentiation
  • myeloid metaplasia with myelofibrosis - multilineage differentiation with marrow fibrosis

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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