diagnosis

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  • Hamm's test or acid-haemolysis test

  • sucrose haemolysis test or sugar water test:
    • a medium of low ionic strength, e.g. isotonic sucrose is used to aggregate serum globulins onto the surface of red cells
    • this activates complement which then lyses PNH red cells
    • the sucrose haemolysis test is more sensitive but less specific than the Ham test and best used as a screen

  • immunophenotype analysis for deficient antigen expression:
    • CD59 for red cells and platelets
    • CD67 for granulocytes
    • CD14 for monocytes
    • CD24 for B cells

Last reviewed 05/2021

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