This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages without signing in

Hypokalaemia

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Hypokalaemia is defined as serum potassium concentration below 3.5 mmol/l (1,2). It can be divided into:

  • mild: 3.1-3.5 mmol/L
  • moderate: 2.5-3.0 mmol/L
  • severe: <2.5 mmol/L

Hypokalaemia is the most common electrolyte abnormality in hospitalised patients.

  • When defined as a value of less than 3.5 mmol/L, hypokalaemia is found in 20% of hospital inpatients but occurs in only 2% of otherwise healthy adults (1)
  • Approximately 5% of hospitalised patients with confirmed hypokalaemia have serum potassium concentrations of <3.0 mmol/l
    • up to 50% of patients with normal potassium on admission may develop hypokalaemia during their inpatient stay
  • an increased risk of hypokalaemia is seen especially in
    • psychiatric patients - due to the medication rather than their underlying illness
    • patients on peritoneal dialysis - due to a combination of K+ loss into peritoneal fluid, infection and poor nutrition (2)

Women are thought to be more susceptible to hypokalaemia than men, especially when given thiazide diuretics. This is probably due to reduced muscle mass and a smaller pool of exchangeable K+ (2)

Pseudo-hypokalemia related to seasonal (summer) changes in ambient temperature has been described in some literature. It is caused by metabolic increases in Na+, K+­- ATPase (‘sodium pump’) activity and cellular uptake of K+ (2).

Note that hypokalaemia exacerbates digoxin toxicity.

Reference:

  1. Jordan M, Caesar J. Hypokalaemia: Improving the investigation, management and therapeutic monitoring of hypokalaemic medical inpatients at a district general hospital. BMJ Open Quality 2015;4:u209049.w3670. doi: 10.1136/bmjquality.u209049.w3670
  2. Unwin RJ, Luft FC, Shirley DG. Pathophysiology and management of hypokalemia: a clinical perspective. Nat Rev Nephrol. 2011;7(2):75-84.

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.