The majority of cases of CLL result from malignant transformation of a B cell; less frequently, of a T cell. In any particular case B or T cell clonality can be established using DNA probes. The malignant lymphocyte is indistinguishable morphologically, from a normal small, relatively mature lymphocyte.
Smear cells are common which have:
CLL differs from multiple myeloma in that CLL is derived from small, relatively mature lymphocytes whereas multiple myeloma is derived form bone marrow plasma cells and their precursors.
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