standard tPA regimen

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The standard regimen for tPA administration is:

  • i.v. infusion of 1.5 mg/kg Alteplase over 3 hr

  • 5000 U i.v. bolus of heparin followed by continuous i.v. infusion over 3 days, maintaining APTT 1.5-2.5

  • 300 mg aspirin chewed, followed by 75-150 mg/day indefinitely

Last reviewed 01/2018