pathological features

Last reviewed 01/2018

The pathological features of cryptogenic fibrosing alveolitis include:

  • migration of large mononuclear cells into the alveolar spaces, associated with acute symptoms
  • thickening of the alveolar walls with fibrosis, associated with chronic disease
  • the pathogenesis is unknown but it is thought there is an alteration in cell-mediated immunity, perhaps activated T lymphocytes increase fibroblastic activity