cystic fibrosis (CF) - related diabetes

Last edited 08/2022 and last reviewed 09/2022

Diagnose cystic fibrosis-related diabetes using one of the following:

  • continuous glucose monitoring (CGM)
  • serial glucose testing over several days
  • oral glucose tolerance testing (OGTT) - if OGTT is abnormal perform CGM or serial glucose testing over several days to confirm the diagnosis.

Test for cystic-fibrosis-related diabetes

  • in people with cystic fibrosis annually from 10 years of age
  • at the end of the first and second trimesters of pregnancy, using CGM or OGTT
  • in people with cystic fibrosis who are taking long-term systemic corticosteroids or receiving enteral tube feeding, using CGM or serial glucose monitoring.

Consider testing for cystic-fibrosis-related diabetes in people who still have any of the following despite optimised cystic fibrosis treatment:

  • unexplained weight loss
  • a deterioration in lung function as measured by spirometry
  • increased frequency of pulmonary exacerbations
  • excessive tiredness.

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