Last reviewed dd mmm yyyy. Last edited dd mmm yyyy
Mexiletine (Namuscla) is recommended, within its marketing authorisation, as an option for treating the symptoms of myotonia in adults with non-dystrophic myotonic disorders (1).
Mexiletine is a class 1b antiarrhythmic medication with a high affinity for muscle sodium channels (2)
In a series of N-of-1 trials of mexiletine vs placebo in patients with nondystrophic myotonia, there was a reduction in mean daily-reported muscle stiffness that was consistent with the treatment effect in a previous randomized clinical trial (3)
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