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Alternative options for women taking continuous combined oral HRT preparation containing 1mg of oestradiol

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Alternative options for women taking continuous combined oral HRT preparation containing 1mg of oestradiol

Women taking continuous combined oral HRT preparation containing 1mg of oestradiol, can consider the following:

  • Bijuve capsule 1mg oestradiol + 100 mg progesterone

  • Femoston conti 1mg oestradiol + 5mg dydrogesterone

  • Kliovance 1mg oestradiol + 0.5mg norethisterone acetate

  • Indivina 1mg oestradiol + 2.5mg medroxyprogesterone acetate

  • Indivina 1mg oestradiol + 5mg medroxyprogesterone acetate

  • Or take oestrogen and progestogen separately:
    • Oral oestradiol 1mg plus either:
      • micronised progesterone: Utrogestan 100 mg orally at night daily on continuous basis
      • Or Provera 5mg orally daily on continuous basis
      • Or Norethisterone 5mg orally daily on continuous basis (1mg would be sufficient for use in a continuous combined regimen but not available in stand-alone preparations)
        • Off license use of norethisterone in progestogen only contraceptive pills (e.g. Noriday 3 x tablets of 350 micrograms a day, will provide 1.05 mg of norethisterone) may be considered as an equivalent alternative
      • Or Mirena IUS

Reference:

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