Mafenide is a broad spectrum antibacterial that is used occasionally for burns. It is applied topically twice a day. It has better solubility in eschar than either silver sulphadiazine or silver nitrate solution. This means that it has been used both for the prophylaxis and treatment of burn infection.
It is a carbonic anhydrase enzyme inhibitor and this leads to many of its side effects:
Last reviewed 01/2018