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Evidence from a systematic review showing the effectiveness of use of antibiotics
in the management of premature rupture of membranes (PROM) (1):
administration of antibiotics after PROM is associated with a delay in delivery
and a reduction in maternal and neonatal morbidity
- penicillins and erythromycin
were associated with similar benefits, but erythromycin was used in larger trials
and, thus, the results are more robust
- amoxicillin/clavulanate should
be avoided in women at risk of preterm delivery because of the increased risk
of neonatal necrotizing enterocolitis
- antibiotic administration after
PROM is beneficial for both women and neonates
NICE note that (2):
S et al. Antibiotics for preterm rupture of membranes: a systematic review.
Obset Gynecol 2004;104:1051-7.
- NICE (August 2019).Preterm
labour and birth
Last edited 08/2019 and last reviewed 08/2019