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2499 pages added, reviewed or updated during the last month (last updated: 18/4/2021)


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haemosiderosis

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Haemosiderosis is a form of iron overload resulting in the accumulation of hemosiderin.

Haemosideosis can occur secondary to transfusions.

Idiopathic pulmonary hemosiderosis may occur.

Notes:

  • Haemosiderin is an insoluble form of iron complexed with protein. It is one form of iron storage within tissue. It is visible microscopically with special stains.

    • haemosiderin is an iron-storage complex. It is always found within cells and appears to be a complex of ferritin, denatured ferritin and other material
      • iron within deposits of hemosiderin is very poorly available to supply iron when needed
      • can be identified histologically with "Prussian-blue" stain.
      • excessive accumulation of hemosiderin is usually detected within cells of the mononuclear phagocyte system or occasionally within epithelial cells of liver and kidney

Last reviewed 01/2018

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