This site is intended for healthcare professionals

2499 pages added, reviewed or updated during the last month (last updated: 18/4/2021)

2499 pages added, reviewed or updated during the last month (last updated: 18/4/2021)


Medical search

corticosteroid withdrawal

FREE subscriptions for doctors and students... click here
You have 3 more open access pages.

Three scenarios present commonly in clinical practice:

  • after long term treatment - where gradual withdrawal of treatment is indicated
  • after short courses of treatment - where abrupt withdrawal may be indicated
  • short-term cessation for surgery

If there is concern about the ability of the adrenal glands to respond after prolonged, high dose therapy:

  • the dose of steroid should be reduced very gradually e.g. 1mg per month of prednisolone
  • the function of the pituitary-adrenal axis can be monitored by:
    • regular plasma ACTH assay
    • plasma cortisol assay: baseline and in response to exogenous ACTH

Note that these treatment recommendations should only be used as a guide due to considerable variability between individuals.

Reference:

  • Current Problems in Pharmacovigilance (1998), 24, 7.

Last reviewed 01/2018

Links: