FREE subscriptions for doctors and students... click here
You have 3 more open access pages.
Three scenarios present commonly in clinical practice:
- after long term treatment - where gradual withdrawal of treatment is indicated
- after short courses of treatment - where abrupt withdrawal may be indicated
- short-term cessation for surgery
If there is concern about the ability of the adrenal glands to respond after prolonged, high dose therapy:
- the dose of steroid should be reduced very gradually e.g. 1mg per month of prednisolone
- the function of the pituitary-adrenal axis can be monitored by:
- regular plasma ACTH assay
- plasma cortisol assay: baseline and in response to exogenous ACTH
Note that these treatment recommendations should only be used as a guide due
to considerable variability between individuals.
- Current Problems in Pharmacovigilance (1998), 24, 7.
Last reviewed 01/2018