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First described by Sir Thomas Hodgkin in 1832 Hodgkin lymphoma (HL) is a malignant proliferation of the lymphoid system.
- the disease is characterised by the presence of multinucleated giant cells (Hodgkin and Reed-Sternberg - HRS) within a cellular infiltrate of non-malignant inflammatory cells that make up the majority of the tumour tissue on histological examination (1)
- HRS cells have been identified clonal B cells that lack typical B-cell surface antigens (1)
HL can be classified as:
- nodular lymphocyte predominant Hodgkin Lymphoma (NLPHL)
- represents about 5% of all cases of the disease
- HRS cells are not present
- classical HL - this is further dived into four sub-types
- nodular sclerosis - accounts for 70% of all classical HL
- mixed cellularity
- lymphocyte-depleted (1)
Last edited 05/2020