syndrome of inappropriate antidiuretic hormone secretion

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This is one of the most common causes of hyponatraemia; patients produce an inappropriately concentrated urine when there is no discernible stimulus for release of antidiuretic hormone (1).

The following criteria should be fulfilled before a diagnosis of SIADH can be made:

persistent excretion of concentrated urine with no reason for ADH release
normal renal and adrenal function
no oedema or hypovolaemia should be present

Reference:

(1) Hoorn EJ, van der Lubbe N, Zietse R. SIADH and hyponatraemia: why does it matter? NDT Plus. 2009;2(Suppl_3):iii5-iii11

Last reviewed 01/2018

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aetiology
clinical features
diagnosis of SIADH
management of SIADH
classification of SIADH

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syndrome of inappropriate antidiuretic hormone secretion