The mainstay of treatment is intravenous amphoteracin B:
Unwanted effects are common, in particular the blood urea should be monitored; if urea becomes significantly elevated then amphoteracin should be stopped until renal function improves.
Addition of flucytosine (150 mg/kg) improves outcome, particularly in patients with AIDS.
Treatment should be for 6 weeks.
Last reviewed 01/2018