Myeloperoxidase is an enzyme stored in neutrophils and monocytes which permits the formation of highly toxic halogen-hydrogen peroxide derivatives e.g. HOCl in the presence of chloride ions. These compounds are advantageous for the destruction of phagocytosed microbes.
Myeloperoxidase deficiency is an autosomal recessive condition. As the production of hydrogen peroxide and oxygen radicals is usually unaffected, there may be no effect clinically. However, some patients are prone to recurrent and persistent bacterial infections.
Last reviewed 01/2018