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The regulation of glycogen synthase is best considered in terms of:
- hepatic enzyme regulation
- skeletal muscle regulation
The key differences between the sites are:
- hepatic glycogen synthase is more closely related to the intracellular glucose concentration, which is in equilibrium with the plasma glucose concentration, than skeletal muscle glycogen synthase
- hepatic glycogen synthase is modulated more closely by both glycogen and insulin
- skeletal glycogen synthase is more sensitive to changes in intracellular calcium concentration
Glycogen synthase acts in opposition to glycogen phosphorylase; the interaction between the two physiological antagonists is considered in the submenu.
Last reviewed 01/2018