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- a 561-patient trial found that a seven-day course of penicillin is better
at resolving symptoms of a streptococcal sore throat than a three-day course.
Symptoms resolved significantly quicker - by half to one day
- the use
of penicillin caused an accelerated resolution of symptoms by 2.5 days in patients
with group A streptococcal sore throat. In those patients with non-group A streptococcal
sore throat there was an accelerated resolution of symptoms by 1.5 days
the prolonged (7-day) penicillin treatment appeared to be protective against the
risk of abscess
NICE have suggested in management of sore throat (2):
Antibiotics for adults aged 18 years and over (a,b,c)
- first choice
- Phenoxymethylpenicillin 500 mg four times a day or 1,000 mg twice
a day for 5 to 10 days
- alternative first choices for penicillin allergy or intolerance
- Clarithromycin 250 mg to 500 mg twice a day for 5 days
- Erythromycin 250 mg to 500 mg four times a day or 500 mg to 1,000 mg
twice a day for 5 days
a. see BNF for appropriate use and dosing in specific populations, for example,
hepatic impairment, renal impairment, pregnancy and breastfeeding.
b. doses given are by mouth using immediate-release medicines, unless otherwise
c. erythromycin is preferred in women who are pregnant.
- NICE (January 2018).Sore
throat (acute): antimicrobial prescribing
Last edited 07/2018