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This a combined preparation of cyproterone acetate with ethinyloestradiol. It has anti-androgenic properties and may be helpful in women who require oral contraception and suffer from acne or hirsutism.
Features of dianette include (1)
- dianette is essentially an oestrogen - dominant oral contraceptive pill
and it carries with it an increased risk of venous thromboembolism similar
to third - generation progestogens
- there are also some additional concerns that cyproterone acetate may cause
liver tumours (benign and malignant) based on animal studies, albeit with
much higher doses. The dianette data sheet recommends that treatment is withdrawn
when the acne has completely resolved. However it also states that repeat
courses may be given if the condition recurs
The Committee on Safety of Medicines notes (2) that dianette is NOT authorised
for the sole purpose of oral contraception and should be discontinued 3 to 4
menstrual cycles after the woman's androgen-related condition has completely
Prescriber are reminded that (2):
- dianette is not indicated for use solely as an oral contraceptive
- dianette is a treatment for women with severe acne that has not responded
to oral antibiotics, or for moderately severe hirsutism
- dianette should be withdrawn 3-4 cycles after the treated condition has
- the incidence of venous thromboembolism is higher than in women who use
low-dose oestrogen COCs
- dianette is contraindicated in women with a personal or close family history
of confirmed, idiopathic venous thromboembolism and in those with a known
current venous thrombotic or embolic disorders
- women who have severe acne or hirsutism may have an inherently increased
- Dermatology in practice (2001), 9 (2), 10-13.
- Current Problems in Pharmacovigilance (2002), 28, 9-10.
Last reviewed 02/2020