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polyarticular onset juvenile idiopathic arthritis
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Polyarticular JIA (poly-JIA) is defined as arthritis of five joints or more during the first 6 months of the disease.
- is the second most common JIA and accounts for 25% to 40% cases.
- prevalence is estimated to be
- 40 per 100,000 children for RF-negative subtype
- 10 per 100,000 children for RF-positive subtype
- more common among girls (1,2)
The condition is further divided into
- rheumatoid factor (RF) positive -
- approximate frequency is between 2-10 %
- more common in later childhood and adolescence
- resembles the adult RF-positive rheumatoid arthritis
- many paediatric rheumatologists consider this JIA subtype to be earlier-onset RA
- RF negative
- approximate frequency is between 11-30 %
- displays a biphasic trend with peaks of onset between 2 and 4 years and 6 and 12 years
- several subgroups have been identified e.g. - resembling early-onset oligoarticular juvenile idiopathic arthritis, resembling adult-onset RF-negative rheumatoid arthritis etc (1,2,3)
The disease is characterised by the insidious (sometimes acute), onset of symmetric arthritis in five or more joints
- involve
- both large and small joints
- cervical spine - frequently
- temparomandibular joints
- mild systemic features e.g. - low-grade fever, lymphadenopathy, and hepatosplenomegaly
- uveitis - an increased incidence is seen in RF-negative subgroup
- RF positive subtype patients are more likely to have symmetric small-joint arthritis, rheumatoid nodules, and early erosive synovitis with a chronic course (1,2,3)
Reference:
- (1) Barut K, Adrovic A, Şahin S, Kasapçopur Ö. Juvenile Idiopathic Arthritis. Balkan Medical Journal. 2017;34(2):90-101.
- (2) Kahn P.Juvenile idiopathic arthritis - an update on pharmacotherapy. Bull NYU Hosp Jt Dis. 2011;69(3):264-76.
- (3) Weinstein SL, Flynn JM. (2013). Juvenile Idiopathic Arthritis. Lovell and Winter’s Pediatric Orthopaedics (7th ed., pp. 348-368)
Last reviewed 01/2018
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