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2499 pages added, reviewed or updated during the last month (last updated: 18/4/2021)


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amphotericin

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Amphotericin is indicated in:

  • intestinal candidiasis by oral route - tablets
  • systemic fungal infections by slow intravenous infusion

Caution must be exercised:

  • with corticosteroids
  • when given parenterally - toxicity is the rule rather than the exception; close supervision is necessary with:
    • hepatic and renal function tests
    • FBC and plasma electrolytes
  • with other nephrotoxic drugs
  • if frequent changes of injection site - irritation
  • with co-administration of antineoplastics

Possible adverse effects include:

  • fever
  • rash
  • nausea, vomiting
  • diarrhoea
  • anorexia
  • myalgia and arthraligia
  • headache
  • biochemical disturbances e.g. hypokalaemia, hypomagnesiumaemia
  • anaemia
  • arrhythmias
  • neurosensory disturbances e.g. hearing loss, peripheral neuropathy, diplopia
  • seizures
  • nephrotoxicity
  • hepatotoxicity
  • phlebitis
  • anaphylaxis

The summary of product characteristics must be consulted before prescribing this drug.

Last reviewed 01/2018

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