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Diagnosis is based upon:
- assays of von Willebrand's Factor:
- increased template bleeding time
- evaluation of vWF protein - vWF:Ag, vWF:R - reduced in type I, normal/reduced in type II, greatly reduced in type III
- ristocetin cofactor activity - ristocetin fails to induce platelet aggregation in von Willebrand's patients because of lack of vWF:R - a cofactor for ristocetin
Last reviewed 01/2018