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2256 pages added, reviewed or updated during the last month (last updated: 21/4/2021)


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cyclosporin A

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This is an immunosuppressive drug that is becoming the drug of choice for transplantation. It may be of use in the management of severe autoimmune diseases.

Cyclosporin blocks cytotoxic T cell activation by:

  • inhibits the formation of a calcineurin-dependent factor essential for the transcription of the interleukin-2 gene, thereby reducing production of interleukin (IL2) by activated T cells and inhibits expression of IL-2 receptors by cytotoxic T cells
  • reduces the response of T helper cells to IL-1
  • does not affect proliferation of suppressor T cells
  • inhibits interferon production by lymphocytes

The bioavailability of cyclosporin A is dependent on the presence of bile salts which may be reduced in patients with liver transplantation. This problem however has been significantly reduced since the advent of a micro-emulsion formulation of cyclosporin whose absorption is independent of bile in the small intestine.

Patients treated with cyclosporin A should have their blood pressure and renal function monitored regularly.

Last reviewed 01/2018

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