The use of prion-contaminated medication, grafts and instruements may result in iatrogenic Creutzfeldt-Jacob disease (CJD).
The clinical features of the disease vary according to the route of innoculation.
Central innoculation, such as an infected dural graft, results in a rapidly progressive neurodegenerative disease similar to sporadic CJD, characterised by:
Peripheral innoculation, such as the old human growth hormone products, results in a slightly less acute disease disease characterised by:
Last reviewed 01/2018