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2288 pages added, reviewed or updated during the last month (last updated: 20/4/2021)


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iatrogenic Creutzfeldt-Jacob disease

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The use of prion-contaminated medication, grafts and instruements may result in iatrogenic Creutzfeldt-Jacob disease (CJD).

The clinical features of the disease vary according to the route of innoculation.

Central innoculation, such as an infected dural graft, results in a rapidly progressive neurodegenerative disease similar to sporadic CJD, characterised by:

  • ataxia
  • dementia
  • myoclonus
  • rididity
  • akinetic mutism
  • survival is 2-12 months from presentation

Peripheral innoculation, such as the old human growth hormone products, results in a slightly less acute disease disease characterised by:

  • progressive cerebellar ataxia
  • dementia is not invariably present
  • survival is 8-18 months from presentation

Last reviewed 01/2018

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