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Drugs used in the medical management of peptic ulcer disease fall into three classes:

  • inhibition of acid secretion - proton pump inhibitors such as omeprazole
  • neutralization of acid - H2 antagonists, e.g. ranitidine 150 mg bd or 300 mg nocte for 4-8 weeks. Ranitidine is preferred because it has fewer side effects and drug interactions than cimetidine
  • increased mucosal resistance:
    • sucralfate - there is some concern about long-term use because of the drug's aluminium content. It may also reduce phenytoin absorption.
    • misoprostol

NICE have produced guidelines as to the management of dyspepsia in primary care (see linked items).

Last reviewed 01/2018

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