This site is intended for healthcare professionals
Medical search
medical management
FREE subscriptions for doctors and students... click here
You have 3 more open access pages.
Drugs used in the medical management of peptic ulcer disease fall into three classes:
- inhibition of acid secretion - proton pump inhibitors such as omeprazole
- neutralization of acid - H2 antagonists, e.g. ranitidine 150 mg bd or 300 mg nocte for 4-8 weeks. Ranitidine is preferred because it has fewer side effects and drug interactions than cimetidine
- increased mucosal resistance:
- sucralfate - there is some concern about long-term use because of the drug's aluminium content. It may also reduce phenytoin absorption.
- misoprostol
NICE have produced guidelines as to the management of dyspepsia in primary care (see linked items).
Last reviewed 01/2018
Links:
- NICE guidance - management of duodenal ulcer (DU) in primary care
- NICE guidance - management of dyspepsia in adults in primary care (summary section)
- neutralization of gastric acid
- improvement of mucosal resistance
- inhibition of gastric acid secretion
- Helicobacter pylori triple therapy
- high fibre
- indications for life-long acid inhibition therapy