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Drugs used in the medical management of peptic ulcer disease fall into three
- inhibition of acid secretion - proton pump inhibitors
such as omeprazole
- neutralization of acid - H2 antagonists, e.g. ranitidine
150 mg bd or 300 mg nocte for 4-8 weeks. Ranitidine is preferred because it has
fewer side effects and drug interactions than cimetidine
- increased mucosal
- sucralfate - there is some concern about long-term
use because of the drug's aluminium content. It may also reduce phenytoin absorption.
NICE have produced guidelines as to the management
of dyspepsia in primary care (see linked items).
Last reviewed 01/2018