The menopause literally means the last menstrual period. The International Menopause Society (IMS) defines menopause (natural menopause) as:
“the permanent cessation of menstruation resulting from the loss of ovarian follicular activity. Natural menopause is recognized to have occurred after 12 consecutive months of amenorrhea, for which there is no other obvious pathological or physiological cause. Menopause occurs with the final menstrual period (FMP) which is known with certainty only in retrospect a year or more after the event. An adequate biological marker for the event does not exist”.
Physiologically, it is characterised by increased production of FSH and LH as negative feedback from serum oestrogen diminishes.
On average, it occurs at 51 years in the U.K., although it can vary between 40 and 58 years of age and it is slightly earlier among smokers (about 2 years earlier than nonsmokers) (2,3).
Sometimes it may be difficult to define precisely when the menopause occurs, especially if the woman begins to take hormone replacement therapy during the menopause.
NICE state that (4):
diagnose the following without laboratory tests in otherwise healthy women aged over 45 years with menopausal symptoms:
Last edited 02/2020 and last reviewed 02/2020