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2288 pages added, reviewed or updated during the last month (last updated: 19/4/2021)


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prostaglandins in burn injury

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Prostaglandins are produced in the early stages of a burn injury. Key mediators include:

  • prostaglandin E2; it increases vascular permeability
  • leukotrienes B4 to D4 increase vascular permeability
  • prostaglandin I2; vasodilator and increased vascular permeability
  • thromboxane A2; causes vasoconstriction in the zone around the burn, so extending the zone of necrosis

Sources include:

  • neutrophils
  • macrophages
  • platelets - for thromboxane A2

In a sheep burn model, anti-inflammatory drugs reduce the levels of prostaglandins but have little effect on oedema.

Last reviewed 01/2018

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