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2256 pages added, reviewed or updated during the last month (last updated: 21/4/2021)


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azathioprine in rheumatoid arthritis

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Azathioprine is a mercaptopurine derivative which has cytotoxic and immunosuppressive effects.

It is used in the treatment of progressive rheumatoid arthritis.

Azathioprine is metabolised to mercaptopurine and then to thioinosinate which interferes with purine metabolism.

The most common side-effects of azathioprine are myelosuppression and hepatotoxicity.

Last reviewed 01/2018

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