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NICE state that (1):
- the use of additional barrier methods should be discussed with women and
girls taking enzyme-inducing anti-epileptic drugs (AEDs) and oral contraception
or having depot injections of progestogen
However FSRH guidance states with respect to depot medroxyprogesterone acetate
(DMPA) or the levonorgestrel-releasing intrauterine system; used concurrently
with enzyme-inducing AEDs
- no interaction and no need for extra precautions
- NICE (April 2018).The
epilepsies: the diagnosis and management of the epilepsies in adults and children
in primary and secondary care.
- Faculty of Sexual & Reproductive Healthcare Clinical Guidance.Clinical Guidance:
Drug Interactions with Hormonal Contraception January 2018.
Last edited 08/2018 and last reviewed 03/2021