Succinate dehydrogenase is an enzyme of the tricarboxylic acid cycle. It is the only enzyme of the cycle found within the mitochondrial membrane.
It catalyzes the reaction of succinate to fumarate with the simultaneous conversion of an FAD co-factor into FADH2. The membranous position of the enzyme facilitates FADH2 access to the electron transport chain at the level of coenzyme Q. The passage of FADH2 down the chain produces 2 molecules of ATP.
Succinate dehydrogenase requires iron to act as a co-factor in its active centre.
Last reviewed 01/2018