Glycosylated haemoglobin (Hb A1) measurement is the most widely used measure of longterm glycaemic control in diabetes.
Glycosylated haemoglobin is produced by the non-enzymatic glycosylation of haemoglobin at a rate proportional to the prevailing glucose concentration. The level of Hb A1 depends upon:
Providing red cell lifespan is normal, Hb A1 measures mean blood glucose concentration over the preceding 60 days - i.e. half-life of red cell.
Some assays measure total glycosylated haemoglobin whilst others measure Hb A1c produced by glycosylation of the N-terminal valine of the B-chain of haemoglobin.
|DCCT- HbA1c (%)||IFCC-HbA1c (mmol/mol)|
Last reviewed 03/2021