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Spironolactone is an aldosterone antagonist (also reduces the activity of the
enzyme Na+K+ATPase in renal tubular cells (1)) used in the treatment of:
- oedema and ascites in liver cirrhosis
- malignant ascites
- nephrotic syndrome
- congestive heart failure
- primary aldosteronism
- severe renal impairment
- pregnancy and breast feeding
- Addison's disease
The summary of product characteristics must be consulted before prescribing
- Prescriber 2004; 15(9):50-6.
Last reviewed 01/2021