FREE subscriptions for doctors and students... click here
You have 3 more open access pages.
Methadone is a synthetic compound with pharmacologic action similar to that
of morphine and heroin, almost equal in addiction liability.
is used as an antitussive and analgesic and as a substitute narcotic in the management
of opiate withdrawal, since it is longer acting than most opiates.
substituted for an abused opiate and then the dose is reduced.
is available as an oral solution (1 mg/ml), an oral concentrate (10 mg/ml), tablets
or injectable ampoules
- methadone has a long elimination half-life (usually
20-37 hours), which allows for a once-daily dosing schedule
appears to have no serious long-term side effects associated with chronic administration
- in the context of opioid dependence management, and using a methadone
maintenance regimen, the drug does not have the pronounced narcotic effects seen
with shorter-acting opioids such as illicit diamorphine
- interactions with
- elimination of methadone is increased by some drugs including
including rifampicin, phenytoin, phenobarbital and some antiviral drugs used in
the treatment of HIV infection
- rate of elimination is reduced by drugs
such as fluvoxamine and fluoxetine
Conult the Summary of
Product Characteristics before prescribing this drug.
or buprenorphine should be offered as the first-line treatment in opioid detoxification.
When deciding between these medications, healthcare professionals should take
- whether the service user is receiving maintenance treatment
with methadone or buprenorphine; if so, opioid detoxification should normally
be started with the same medication
- the preference of the service user.
(January 2007).Methadone and buprenorphine for the management of opioid dependence
(July 2007).Drug misuse - Opioid detoxification
Last reviewed 01/2018