Loeffler's endocarditis

Eosinophilic endomyocardial disease is characterized by:

endomyocardial fibrosis
a high incidence at temperate latitudes
large mural thrombi
eosinophilia with infiltration of organs especially the heart (causing restrictive cardiomyopathy)
rapid fatality

This disease is closely related to the African condition of endomyocardial fibrosis (qv).

Treatment measures include:

suppression of eosinophilia e.g. prednisolone or hydroxycarbamide (former British Approved Name, hydroxyurea)
digoxin
diuretics

Last reviewed 01/2018

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