The SPRINT trial had to be prematurely terminated after recruiting 1358 patients because the use of nifedipine increased mortality following acute myocardial infarction.
Patients were randomised within 48 hr of a myocardial infarction to:
Mortality at 6 months in the placebo group was 13.3% compared to 15.4% in the nifedipine group.
The conclusion is that routine use of calcium channel blockers following myocardial infarction should be avoided.
Last reviewed 01/2018