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2264 pages added, reviewed or updated during the last month (last updated: 21/4/2021)


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SPRINT trial (nifedipine after MI)

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The SPRINT trial had to be prematurely terminated after recruiting 1358 patients because the use of nifedipine increased mortality following acute myocardial infarction.

Patients were randomised within 48 hr of a myocardial infarction to:

  • nifedipine 60 mg/day
  • placebo

Mortality at 6 months in the placebo group was 13.3% compared to 15.4% in the nifedipine group.

The conclusion is that routine use of calcium channel blockers following myocardial infarction should be avoided.

Reference:

Last reviewed 01/2018

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