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2288 pages added, reviewed or updated during the last month (last updated: 20/4/2021)


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rickets

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Rickets is the consequence of poor bone mineralisation. It is the childhood equivalent of osteomalacia

  • commonest cause of rickets is simple nutrient deficiency of vitamin D (from sunlight, diet or both), ie. deficiency in the absence of any other cause such as malabsorption, or disorders of the liver, kidneys or metabolism

Clinical features summary:

  • classically present with bony abnormalities such as leg-bowing and knock-knees
    • may also be bony deformities of the chest, pelvis and skull, fractures in severe cases, delayed dentition, poor growth, and, rarely, bone pain
  • may present with symptoms of hypocalcaemia, such as neuromuscular irritability (e.g. convulsions, tetany), cardiomyopathy or cardiac arrest may be the presenting feature, especially in very young infants

Vitamin D deficiency in children

  • overall prevalence of vitamin D deficiency in children in the UK is not known
  • appears particularly prevalent among non-European ethnic minorities
    • evidence from observational studies suggest that, in these minority groups, vitamin D deficiency occurs:
      • in around 50% of pregnant women and their neonates, up to 40% of toddlers, up to 45% of schoolchildren and over 70% of adolescents

Reference:

  1. Drug and Therapeutics Bulletin 2006; 44(2):12-16.

Last reviewed 01/2018

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