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clinical features of hyperthyroidism

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	symptoms	signs
constitutional	weight loss despite increased appetite heat related symptoms – heat intolerance, sweating, polydypsia	weight loss
neuromuscular	tremor nervousness anxiety fatigue weakness disturbed sleep poor concentration	tremor of the extremities hyperactivity hyper-reflexia pelvic and girdle muscle weakness
cardiovascular	palpitations	tachycardia systolic hypertension irregular heartbeat (atrial fibrillation)
pulmonary	dyspnoea	tachypnoea
gastrointestinal	hyperdefecation nauses vomiting	abdominal tenderness
skin	increased perspiration	warm and moist skin
reproductive		menstrual disturbances
ocular	diplopia sense of irritation in the eyes eyelid swelling retro-orbital pain or discomfort	proptosis eyelid retraction and lag periorbital oedema conjunctival injection and chemosis ophthalmoplegia (1)

Clinical features can also be considered in terms of typical and atypical presentations of hyperthyroidism..

Reference:

(1) De Leo S, Lee SY, Braverman LE. Hyperthyroidism. Lancet (London, England). 2016;388(10047):906-918.

Last edited 04/2018

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